"I don’t usually wish ex-girlfriends Happy Birthday. But Betty’s special. Happy Birthday to the one and only, Betty White," followed by a birthday cake emoji.
The duo are both renowned for their quick wit, and have known each other since she portrayed his grandmother in the 2009 rom-com, The Proposal, alongside Sandra Bullock.
Sandra Bullock, Reynolds and White filmed a GAS Funny or Die promotional video for the film, and it seems they've been best friends ever since.
After Deadpool premiered in 2016, White made her own review for the flick; "Hello, I just saw the most anticipated movie of the year," White said about the Reynolds-made movie, while lounging in a red velvet chair.
"It was glorious. Once in a generation, a movie comes along that your whole family will love. If your family is a f*cking group of ass-kissing inbreds," she jokingly dead-panned. "Plus, Ryan Reynolds looks so f*cking handsome in his red leather suit."
Reynolds wished White a happy birthday back in 2018 with an amusing photo of himself wearing his Deadpool costume on Instagram, holding a martini and hot dog.
It's been less than 10 days since stuntwoman, SJ Harris, died while performing on the set of Deadpool 2.
And as the entertainment industry comes to terms with her untimely passing, reports are circulating that the crew had expressed concern over SJ's capabilities.
However, it seems 20th Century Fox producers failed to heed the crew's warning due to their desire to use an individual who was a believable stand-in for actress Zazie Beetz.
Speaking to Hollywood Reporter, film insiders admitted that they feared for SJ's safety in the run-up to the shooting, due to the fact SJ had never worked on a film set.
“She was improving, but I was watching her and, oh my God, I thought, ‘It’s just a matter of time before she crashes into a wall or runs somebody over," said one stunt performer who had been training SJ.
“I cringed every time she went out," added another set insider. “They were warned, yes!”
40-year-old SJ's fatal crash occurred during her first live take on the Vancouver set.
According to Hollywood Reporter, Deadpool 2 director David Leitch has declined to comment, and the production is still on track for its June 1 release.
Commenting on SJ's death in the days that followed, Deadpool star, Ryan Reynolds, said: "We’re heartbroken, shocked and devastated, but recognise nothing can come close to the grief and inexplicable pain her family and loved ones must feel in this moment."
"My heart pours out to them – along with each and every person she touched in this world."
Ryan finished the message with a nod to the impact SJ had throughout her life, concluding: "My heart pours out to them – along with each and every person she touched in this world."
The tweet, which has amassed more than 136,000 likes since its upload last night, has ignited debate over whether the film should be cancelled in the wake of her death – a suggestion which was dismissed by many of Ryan's followers.
A motorcycle lays on the ground just across from Jack Poole plaza. You can't see here but above it is broken glass pic.twitter.com/zzl5Ag9gYT
"They finished The Crow and the freaking star of the movie died. This is awful but a risk of the job," countered one member of the public.
"And Gladiator. Oliver Reed died during filming and they got a stand in," added another.
Paying tribute to the skill and talent exhibited by stunt actors within the industry, one Twitter user wrote: "it's about time that stunt people get recognised at the Oscars or similar level awards. You couldn't make movies without them!"